Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
USERS' SCORE
Moderately Good
Based on 36 Reviews
7.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
667 mcg DFE (400 mcg Folic Acid)
167%
Calcium (as Calcium Carbonate)
100 mg
8%
Top Medical Research Studies
8
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Read More
9
We explored the potential benefits of folic acid in treating dangerous heart rhythm problems linked to TANGO2-deficiency disorder (TDD). By creating patient-derived heart cell models, we observed that high doses of folate significantly reduced these arrhythmias. Additionally, clinical studies indicated that taking multivitamins, particularly those rich in B complex, lowered the chance of heart crises in TDD patients. Together, these findings suggest that B vitamins, including folate, could be vital in managing severe heart complications associated with this rare genetic disorder.
Read More
8
We investigated whether folic acid treatment could help lower heart disease risk related to elevated homocysteine levels. The study highlighted that hyperhomocysteinemia is a significant independent risk factor for atherosclerosis, which can contribute to serious cardiovascular events. While folic acid, alongside other B vitamins, effectively reduces homocysteine levels, it does not appear to significantly improve heart disease outcomes on its own. Thus, while folic acid plays a role in managing homocysteine, its impact on preventing heart disease is less clear.
Read More
Most Useful Reviews
7.5
Affordability and quality
6 people found this helpful
Folic acid is beneficial not only for women planning pregnancy but also for men, helping with heart health and immunity. It has an excellent price/quality ratio and lasts over a month, making it a wise investment in health, especially concerning heart disease.
Read More
9
Enhanced health
4 people found this helpful
Folic acid has significantly improved my hair, nails, and overall health. It provides energy and has positively changed my daily routine. I take it once daily, and it has helped me feel better overall, impacting my heart health positively.
Read More
9
Boosts heart function
2 people found this helpful
Folic acid restores the immune system and supports the heart and blood vessels. It stimulates organ activity, especially for the skin and promotes normal hair growth. This vitamin is particularly important during pregnancy, with a recommended daily intake of 400 mg.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
- All Researches
9
Maternal folic acid reduces CHD risk
We explored how maternal folic acid supplementation relates to congenital heart disease (CHD) in children. Through a case-control study involving 595 children with CHD and 605 healthy controls, we found that mothers taking folic acid significantly reduced the risk of CHD and its subtypes. Notably, variations in the MTRR gene among offspring were linked to higher CHD risks, but maternal folic acid appeared to mitigate some of this risk. While results are promising, further research with larger samples is essential to fully understand these findings.
Read More
9
We explored the potential benefits of folic acid in treating dangerous heart rhythm problems linked to TANGO2-deficiency disorder (TDD). By creating patient-derived heart cell models, we observed that high doses of folate significantly reduced these arrhythmias. Additionally, clinical studies indicated that taking multivitamins, particularly those rich in B complex, lowered the chance of heart crises in TDD patients. Together, these findings suggest that B vitamins, including folate, could be vital in managing severe heart complications associated with this rare genetic disorder.
Read More
8
We investigated whether folic acid treatment could help lower heart disease risk related to elevated homocysteine levels. The study highlighted that hyperhomocysteinemia is a significant independent risk factor for atherosclerosis, which can contribute to serious cardiovascular events. While folic acid, alongside other B vitamins, effectively reduces homocysteine levels, it does not appear to significantly improve heart disease outcomes on its own. Thus, while folic acid plays a role in managing homocysteine, its impact on preventing heart disease is less clear.
Read More
8
We explored how folic acid affects patients with coronary heart disease (CHD) and hypertension, particularly considering the MTHFR C677T gene. The study included 540 patients who received either folic acid treatment alongside enalapril or standard care.
While both folic acid and non-folic acid groups showed lower rates of cardiovascular events compared to the control group, the results suggested folic acid may enhance patient outcomes in those with H-type hypertension. Overall, folic acid seems to support better blood pressure management and improves prognosis among high-risk patients, highlighting the importance of genetic screening in treatment.
While both folic acid and non-folic acid groups showed lower rates of cardiovascular events compared to the control group, the results suggested folic acid may enhance patient outcomes in those with H-type hypertension. Overall, folic acid seems to support better blood pressure management and improves prognosis among high-risk patients, highlighting the importance of genetic screening in treatment.
Read More
8
We explored a new silk fibroin and hydroxypropyl cellulose hydrogel designed to improve heart repair after a myocardial infarction by using folic acid-modified extracellular vesicles (EVs). This method aims to overcome the challenge of EV retention in the heart.
Our findings suggest that the hydrogels not only support cell viability but also boost cell migration, contributing to tissue repair by reducing fibrosis and enhancing blood vessel growth in heart tissue. In essence, this innovative approach shows promise for advancing treatments for heart damage.
Our findings suggest that the hydrogels not only support cell viability but also boost cell migration, contributing to tissue repair by reducing fibrosis and enhancing blood vessel growth in heart tissue. In essence, this innovative approach shows promise for advancing treatments for heart damage.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 36 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Affordability and quality
6 people found this helpful
Folic acid is beneficial not only for women planning pregnancy but also for men, helping with heart health and immunity. It has an excellent price/quality ratio and lasts over a month, making it a wise investment in health, especially concerning heart disease.
Read More
9
Enhanced health
4 people found this helpful
Folic acid has significantly improved my hair, nails, and overall health. It provides energy and has positively changed my daily routine. I take it once daily, and it has helped me feel better overall, impacting my heart health positively.
Read More
9
Boosts heart function
2 people found this helpful
Folic acid restores the immune system and supports the heart and blood vessels. It stimulates organ activity, especially for the skin and promotes normal hair growth. This vitamin is particularly important during pregnancy, with a recommended daily intake of 400 mg.
Read More
7.5
Prevents heart issues
2 people found this helpful
It's a myth that folic acid is only needed during pregnancy. It’s crucial for cell growth and DNA integrity, which prevents tumours. It supports the immune system, heart, and blood vessels, and plays a role in amino acid synthesis, positively affecting mood and performance.
Read More
9
Improves heart health
1 people found this helpful
Folic acid is essential, supporting immune function, heart health, and blood cell formation. It assists in nucleic and amino acid synthesis, promoting new cell growth while preserving existing cells, keeping skin fresh and hair vibrant. Regular intake improves mood, especially during PMS and menopause.
Read More
Frequently Asked Questions
9
Good for energy
The quality is excellent, and the folic acid contributes to energy and nervous system metabolism. With 120 pills, it lasts four months. I've noticed benefits within two weeks. Thank you, iHerb!
7.5
Convenient heart support
1 people found this helpful
Folic acid is vital for blood vessel and heart support. My gynaecologist prescribed it due to poor blood clotting results. The vitamins suit me well, are conveniently packaged, and the neutral taste is fine. I feel more energetic with improved metabolism and nervous system function.
9
Enhanced health
4 people found this helpful
Folic acid has significantly improved my hair, nails, and overall health. It provides energy and has positively changed my daily routine. I take it once daily, and it has helped me feel better overall, impacting my heart health positively.
9
Improved energy levels
22 people found this helpful
The quality of this supplement is excellent. It helped alleviate my folic acid deficiency, increased my energy, and improved my hair, skin, and nails without side effects. It also positively impacted my nervous system and metabolism. I will definitely purchase it again.
9
Improves heart health
1 people found this helpful
Folic acid is essential, supporting immune function, heart health, and blood cell formation. It assists in nucleic and amino acid synthesis, promoting new cell growth while preserving existing cells, keeping skin fresh and hair vibrant. Regular intake improves mood, especially during PMS and menopause.
7.5
Supports heart function
1 people found this helpful
Folic acid aids in cell formation, enhancing skin smoothness, hair density, and nail strength. For maximum benefit, combine it with B12 and B6. It supports heart health by reducing heart disease risk and strengthens blood vessel walls, promoting red and white blood cell production.
6
Anemia treatment
5 people found this helpful
I take folic acid alongside iron supplements to enhance iron absorption and address anaemia. It’s often thought to be just for pregnant women, but it’s necessary for anyone, especially those with chronic gastrointestinal issues. I’ve seen improvements in my haemoglobin levels without side effects.
9
Heart health recommendation
An excellent supplement for maintaining heart function. I recommend it.
7.5
Supports heart function
Vitamin B9 assists in amino acid metabolism and DNA production, which is vital for rapidly regenerating cells. It lowers homocysteine levels in blood, thus preventing heart disease. It's also crucial for women during pregnancy for proper fetal nervous system formation.
7.5
Supports heart health
1 people found this helpful
Great price! Good dosage. Folic acid contributes to normal heart function and reduces heart disease risk. It strengthens blood vessel walls and aids in producing red and white blood cells.
9
Maternal folic acid reduces CHD risk
We explored how maternal folic acid supplementation relates to congenital heart disease (CHD) in children. Through a case-control study involving 595 children with CHD and 605 healthy controls, we found that mothers taking folic acid significantly reduced the risk of CHD and its subtypes. Notably, variations in the MTRR gene among offspring were linked to higher CHD risks, but maternal folic acid appeared to mitigate some of this risk. While results are promising, further research with larger samples is essential to fully understand these findings.
8
We explored how folic acid affects patients with coronary heart disease (CHD) and hypertension, particularly considering the MTHFR C677T gene. The study included 540 patients who received either folic acid treatment alongside enalapril or standard care.
While both folic acid and non-folic acid groups showed lower rates of cardiovascular events compared to the control group, the results suggested folic acid may enhance patient outcomes in those with H-type hypertension. Overall, folic acid seems to support better blood pressure management and improves prognosis among high-risk patients, highlighting the importance of genetic screening in treatment.
While both folic acid and non-folic acid groups showed lower rates of cardiovascular events compared to the control group, the results suggested folic acid may enhance patient outcomes in those with H-type hypertension. Overall, folic acid seems to support better blood pressure management and improves prognosis among high-risk patients, highlighting the importance of genetic screening in treatment.
8
We investigated whether folic acid treatment could help lower heart disease risk related to elevated homocysteine levels. The study highlighted that hyperhomocysteinemia is a significant independent risk factor for atherosclerosis, which can contribute to serious cardiovascular events. While folic acid, alongside other B vitamins, effectively reduces homocysteine levels, it does not appear to significantly improve heart disease outcomes on its own. Thus, while folic acid plays a role in managing homocysteine, its impact on preventing heart disease is less clear.
5
We assessed the impact of B vitamin supplements on patients with chronic heart failure. By analyzing a group of 150 diagnosed individuals, we measured the effects of folic acid and other B vitamins on heart function markers.
Results revealed that these supplements slightly improved heart performance but did not show a significant overall benefit in treating heart disease specifically. While slight improvements were noted like reduced heart rate and increased pressure metrics, more research is needed to refine these insights into practical treatment strategies.
Results revealed that these supplements slightly improved heart performance but did not show a significant overall benefit in treating heart disease specifically. While slight improvements were noted like reduced heart rate and increased pressure metrics, more research is needed to refine these insights into practical treatment strategies.
References
- Ruan X, Shang W, Lu J, Li Z, Yang J, et al. Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor total volatile organic compounds exposure in east china: a case-control study. Environ Health. 2024;23:110. doi:10.1186/s12940-024-01150-7
- Li L, Ou J, Chen Y, Chen Q, Luo M, et al. Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population. J Health Popul Nutr. 2024;43:220. doi:10.1186/s41043-024-00699-w
- Prasad K. Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment. Int J Angiol. 2024;33:262. doi:10.1055/s-0044-1788280
- Ma L, Zeng L, Wang X. MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension treated with enalapril and folic acid: implications for prognosis. Cell Mol Biol (Noisy-le-grand). 2024;70:142. doi:10.14715/cmb/2024.70.9.20
- Ruan XR, Sun MT, Wei JH, Luo MJ, Liu HJ, et al. [Maternal gene polymorphisms and their interactions with periconceptional folic acid supplementation in relation to offspring ventricular septal defects]. Zhongguo Dang Dai Er Ke Za Zhi. 2024;26:899. doi:10.7499/j.issn.1008-8830.2403067
- Xu W, Cao Y, Stephens SB, Arredondo MJ, Chen Y, et al. Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder. JCI Insight. 2024;9. doi:10.1172/jci.insight.171005
- Hua Y, He Z, Ni Y, Sun L, Wang R, et al. Silk fibroin and hydroxypropyl cellulose composite injectable hydrogel-containing extracellular vesicles for myocardial infarction repair. Biomed Phys Eng Express. 2024;10. doi:10.1088/2057-1976/ad40b2
- Liu L, Zhang X, Geng HR, Qiao YN, Gui YH, et al. High paternal homocysteine causes ventricular septal defects in mouse offspring. iScience. 2024;27:109447. doi:10.1016/j.isci.2024.109447
- Sobot T, Bajic Z, Skrbic R, Uletilovic S, Mandic-Kovacevic N, et al. Effect of folic acid on isoprenaline-induced myocardial injury in rats. Physiol Int. 2024;111:80. doi:10.1556/2060.2023.00291
- Bennett DA, Parish S, Millwood IY, Guo Y, Chen Y, et al. MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults. Int J Epidemiol. 2023;52:1862. doi:10.1093/ije/dyad147
- Chen L, Yang T, Wang T, Sun M, Qin J. Relationships between Maternal Folic Acid Supplementation and Gene Polymorphisms in Patients with Non-Chromosomal Congenital Heart Disease: A Hospital-Based Case-Control Study in China. Nutrients. 2023;15. doi:10.3390/nu15204478
- Ju DT, Huang RS, Tsai BC, Su YC, Chiu PL, et al. Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer's Disease mice via IGF1R/PI3K/AKT and SIRT1/AMPK Pathways. Neurotox Res. 2023;41:648. doi:10.1007/s12640-023-00666-z
- Dkhillon D, Samogulova A, Kolobov B. B Vitamins as Adjunctive Treatment for Chronic Heart Failure. Cardiovasc Hematol Disord Drug Targets. 2023;23:64. doi:10.2174/1871529X23666230719090419
- Webber DM, Li M, MacLeod SL, Tang X, Levy JW, et al. Gene-Folic Acid Interactions and Risk of Conotruncal Heart Defects: Results from the National Birth Defects Prevention Study. Genes (Basel). 2023;14. doi:10.3390/genes14010180
- Qu Y, Liu X, Lin S, Bloom MS, Wang X, et al. Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring. JAMA Netw Open. 2024;7:e2438747. doi:10.1001/jamanetworkopen.2024.38747
